| 翻訳と辞書 |
HKA test
The HKA Test, named after Richard R. Hudson, Martin Kreitman, and Montserrat Aguadé, is a statistical test used in genetics to evaluate the predictions of the Neutral Theory of molecular evolution. By comparing the polymorphism within each species and the divergence observed between two species at two or more loci, the test can determine whether the observed difference is likely due to neutral evolution or rather due to adaptive evolution. Developed in 1989, the HKA test is a precursor to the McDonald-Kreitman test, which was derived in 1991. The HKA test is best used to look for balancing selection, recent selective sweeps or other variation-reducing forces.
==Neutral Evolution==
Neutral Evolution Theory, first proposed by Kimura in a 1968 paper, and later fully defined and published in 1983, is the basis for many statistical tests that detect selection at the molecular level. Kimura noted that there was much too high of a rate of mutation within the genome (i.e. high polymorphism) to be strictly under directional evolution. Furthermore, functionally less important regions of the genome evolve at a faster rate. Kimura then postulated that most of the modifications to the genome are neutral or nearly neutral, and evolve by random genetic drift. Therefore, under the neutral model, polymorphism within a species and divergence between related species at homologous sites will be highly correlated. The Neutral Evolution theory has become the null model against which tests for selection are based, and divergence from this model can be explained by directional or selective evolution.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
■ウィキペディアで「HKA test」の詳細全文を読む
スポンサード リンク
| 翻訳と辞書 : 翻訳のためのインターネットリソース |
Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.
|
|